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Accutane is a pharmaceutical that is prescribed by a doctor. It is used in the treatment of severe nodular and cystic forms of acne (acne), when numerous inflammatory nodes with purulent contents appear on the skin, leave distorting scars, and all other remedies have no effect.

Accutane belongs to a group of drugs called retinoids because they are derivatives of vitamin A – retinol. When a pregnant woman consumes retinoids, this can lead to very serious fetal malformations.

Accutane (the original chemical name is isotretinoin) is a synthetic derivative of vitamin A that is manufactured and marketed by Roche Dermatologics, a division of the pharmaceutical company Hoffman-La Roche, Inc. After the U.S. Food and Drug Administration (FDA) recognized the drug in 1982, it was widely used to treat severe forms of acne. Hundreds of thousands of people in the United States suffer from nodular acne, and often no remedy can help but Accutane. After using the drug, even severely affected skin is cleaned for a long period.

But before the drug was widely recognized, clinical trials in animals have shown that it can cause fetal malformations. Following these results, Roche began to warn pregnant women with Accutane.

How does Accutane work?

When you take Accutane, it compresses the sebaceous glands of the skin, which are responsible for the production of sebum. Each fat is a substance, and its excess production can lead to various skin problems, such as acne.

Excessive sebum blocks the sebaceous glands. This causes accumulation under the skin. The bacteria that cause cystic acne, as a rule, thrive in this state, because sebum is food.

When blackheads feed on sebum in your skin, they produce fatty acids. Acids irritate the sebaceous glands and cause them to become inflamed. As a result, spots on the skin and acne also occur.

Thus, when Accutane contracts the sebaceous glands, the amount of their production of sebum decreases. As a result, clogging of the cutaneous nucleus is also minimized. Given that acne mainly occurs due to clogged skin pores with sebum, the effect of this drug controls them.

This prevents clogging of the sebaceous glands, so there is a minimal chance that bacteria will reappear on the skin. The drug also reduces skin inflammation. This reduces their ability to form acne and white acne.

How high is the risk of Accutane during pregnancy?

If a woman becomes pregnant during the treatment with Accutane, the risk of fetal malformations is extremely high, even if she takes the drug for a short time and in small doses. Disadvantages of fetal development with Accutane administration include hydrocephalus (an increase in fluid-filled brain cavities), microcephaly (especially a small head), mental retardation, ear, and eye abnormalities, splitting of the lips and palate, other parts of the face, heart defects.

There is also a high risk of miscarriage by women taking the drug. Accutane can cause these side effects in the fetus when a woman takes it in the first few weeks after fertilization, often not yet knowing that she is pregnant. Even in children without visible physical defects, mental retardation, or learning problems may occur.

Accutane is undoubtedly the last stage of acne treatment, especially for severe cases where the use of antibiotics and topical acne medications, was useless. The most amazing thing is that often it takes only 16 to 20 weeks to get rid of the disease once and for all.